Mapping the development of lung structures in children with genetic lung disease
A mechanistic 3D AI-powered map of genetic chILD
This study is working to create a detailed 3D map of the lungs in children with childhood interstitial lung disease (chILD) to better understand how genes affect lung growth and health, which could lead to improved treatments for these kids.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10974509 on NIH RePORTER |
What this research studies
This research aims to create a detailed 3D map of lung structures in children, focusing on those with childhood interstitial lung disease (chILD). By using advanced technologies like artificial intelligence and high-resolution imaging, the team will explore how genetic factors influence lung development and function. The project will involve analyzing patient-derived cells and utilizing bioinformatics to understand cellular interactions and pathways. The findings will be shared with the medical community to enhance knowledge and treatment options for lung diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have been diagnosed with childhood interstitial lung disease.
Not a fit: Patients who are older than 11 years or do not have any form of lung disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of lung diseases in children, potentially enhancing their quality of life.
How similar studies have performed: Previous phases of the LungMAP project have shown success in mapping lung structures, indicating a promising foundation for this new research.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Xu, Yan — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Xu, Yan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.