Mapping the connections and structures of the mouse hypothalamus
Official title: A three dimensional multimodal cellular connectivity atlas of the mouse hypothalamus
Funded at University of California Los Angeles · NIH-11079668 · Data updated 2026-11-12
This study is looking at a part of the brain in mice that helps control important survival behaviors, and by creating a detailed 3D map, the researchers hope to learn more about the different types of brain cells there and how they work together, which could help us understand behaviors better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $648,637 |
| NIH project number | 5R01NS133744-03 |
| Project ID | NIH-11079668 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals interested in neurological conditions or behavioral disorders linked to hypothalamic functions.
✕Less likely to help
Patients with conditions unrelated to hypothalamic function or those not affected by aggression-related behaviors may not receive direct benefits from this research.
What this research studies
This research investigates the complex organization of the hypothalamus in mice, focusing on the lateral hypothalamic area (LHA), which is crucial for survival behaviors. By creating a detailed 3D atlas, the study aims to understand the diverse neuron types and their connections within this brain region. The researchers will utilize advanced imaging techniques and computational methods to analyze the structural and functional aspects of the LHA, considering differences between male and female mice. This comprehensive approach may reveal insights into how specific neuron types contribute to various behaviors.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain functions related to aggression and other survival behaviors, potentially leading to new therapeutic strategies for related disorders.
How similar studies have gone: While the specific approach of creating a multimodal atlas is innovative, similar studies have shown success in mapping brain structures and their functions, indicating potential for impactful findings.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Dong, Hong-Wei — University of California Los Angeles
- Study coordinator: Dong, Hong-Wei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.