Mapping the complete set of human protein-coding genes
Generating a full-length reference transcriptome for human protein-coding genes
This study is working to map out all the different versions of human genes that make proteins, which can help us understand how these genes behave in health and illness, and it could provide useful information for patients about their specific conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10881907 on NIH RePORTER |
What this research studies
This research aims to create a comprehensive reference transcriptome that details all the protein-coding genes in humans. By utilizing advanced sequencing techniques, the project will identify and characterize various isoforms of these genes, which can differ significantly in their expression levels across different tissues and conditions. This work is crucial for understanding how these genes function in health and disease, as well as how they respond to various stimuli. Patients may benefit from insights gained into the roles of specific gene isoforms in their conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic disorders or diseases linked to specific protein-coding genes.
Not a fit: Patients with conditions unrelated to the protein-coding genes being studied may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic contributions to diseases and better-targeted therapies.
How similar studies have performed: Previous research has shown success in characterizing gene isoforms, indicating that this approach has the potential for significant advancements in understanding human genetics.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Vidal, Marc — Dana-Farber Cancer Inst
- Study coordinator: Vidal, Marc
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.