Mapping the cellular organization of the human brain.
Cell type atlasing of whole human brains using HOLiS: an optimized pipeline for staining, clearing, imaging, and analysis
This study is working on making a detailed map of the human brain's cells to help scientists better understand how our brains work and what makes us think and behave the way we do.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10377810 on NIH RePORTER |
What this research studies
This research aims to create a detailed map of the human brain's cellular structure using advanced imaging techniques. By employing a novel pipeline that includes optimized tissue processing, ultra-fast 3D microscopy, and efficient data analysis, the project seeks to visualize the entire human brain at a cellular level. This comprehensive approach will help researchers understand complex brain functions and the underlying cellular organization that contributes to human cognition and behavior.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with neurological conditions or those interested in brain health and cognition.
Not a fit: Patients with acute brain injuries or those who do not have access to the necessary imaging technologies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding brain disorders and improving treatments for neurological conditions.
How similar studies have performed: Previous research has shown success in mapping mouse brains using similar techniques, indicating potential for success in human applications.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Hillman, Elizabeth M. C. — Columbia University Health Sciences
- Study coordinator: Hillman, Elizabeth M. C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.