Mapping the cellular landscape of Autosomal Dominant Polycystic Kidney Disease
Official title: Constructing Mouse and Human Single-cell Atlas in Autosomal Dominant Polycystic Kidney Disease
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-10950872 · Data updated 2026-11-12
This study is looking at how certain genetic changes in people and mice with Autosomal Dominant Polycystic Kidney Disease (ADPKD) affect the disease and its symptoms, with the hope of finding new ways to help improve treatments for patients like you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $135,582 |
| NIH project number | 1R21DK140693-01 |
| Project ID | NIH-10950872 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Autosomal Dominant Polycystic Kidney Disease, particularly those with varying genetic mutations.
✕Less likely to help
Patients without a diagnosis of Autosomal Dominant Polycystic Kidney Disease or those with unrelated kidney conditions may not benefit from this research.
What this research studies
This research aims to create a detailed cellular atlas of both mouse and human models of Autosomal Dominant Polycystic Kidney Disease (ADPKD). By examining the genetic mutations associated with ADPKD, the study seeks to understand how these variations affect disease severity and progression. The researchers will utilize advanced techniques to analyze immune cell functions and other cellular interactions in different models, which may help identify new therapeutic targets. This comprehensive approach could lead to better treatment options for patients suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to the development of new and more effective treatments for patients with Autosomal Dominant Polycystic Kidney Disease.
How similar studies have gone: Previous research has shown promise in using cellular mapping techniques to understand complex diseases, indicating that this approach could yield valuable insights for ADPKD.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Zimmerman, Kurt a — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Zimmerman, Kurt a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.