Mapping the 3D structure of tumors to understand cancer progression
Tech Core 2
This study is working on new ways to make detailed 3D maps of tumor cells to see how they behave and spread, especially in breast cancer, which could help find better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10994092 on NIH RePORTER |
What this research studies
This research focuses on developing advanced techniques to create detailed 3D maps of tumor cells, which can reveal how cancer cells interact with their environment and contribute to cancer spread. By integrating tissue images with deep learning algorithms, the project aims to uncover the complex anatomy of tumors at a single-cell level. Additionally, it seeks to gather molecular information about the cells to identify new therapeutic targets and mechanisms. This innovative approach could lead to better understanding and treatment of cancers, particularly breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with breast cancer or other cancers where tumor heterogeneity plays a significant role.
Not a fit: Patients with non-cancerous conditions or those whose tumors do not exhibit significant spatial heterogeneity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by identifying new targets for therapy and improving our understanding of tumor behavior.
How similar studies have performed: Other research has shown promise in using 3D imaging and multi-omics approaches to study tumors, indicating that this method could be a significant advancement in cancer research.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Wirtz, Denis — Johns Hopkins University
- Study coordinator: Wirtz, Denis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.