Mapping the 3D structure of the human genome across different tissues
Ultra-high resolution 3D genome maps for multiple human tissues
This study is working on creating super-detailed 3D maps of our genes to learn how they work in different parts of the body, which could help us find better treatments for diseases related to gene regulation.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10986325 on NIH RePORTER |
What this research studies
This research aims to create ultra-high resolution 3D maps of the human genome to better understand how gene expression is regulated in various tissues. By focusing on the interactions between enhancers and promoters, which are crucial for activating genes, the study will utilize advanced genomic data from multiple projects to identify these interactions more accurately. Patients may benefit from insights gained about how different tissues express genes, potentially leading to improved treatments for diseases linked to gene regulation. The methodology involves analyzing large datasets and employing sophisticated computational models to visualize and interpret the complex 3D structure of the genome.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to gene expression and regulation, such as genetic disorders or cancers.
Not a fit: Patients with conditions unrelated to gene regulation or those not affected by genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding gene regulation, which may improve treatment strategies for various diseases.
How similar studies have performed: Previous research has shown success in mapping genomic interactions, but this approach aims to provide a more comprehensive and detailed understanding, making it a novel endeavor.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Liu, Jie — University of Michigan at Ann Arbor
- Study coordinator: Liu, Jie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.