Mapping the 3D structure of the brain's genetic regulation during development and disease
Charting the 3D epigenome in human brain development and diseases
This study is looking at how the way our genes are organized in 3D affects brain development and could lead to conditions like autism, with the hope that the findings will help us understand more about these issues and improve care for those affected.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10911120 on NIH RePORTER |
What this research studies
This research investigates how the three-dimensional structure of the genome influences brain development and the onset of neuropsychiatric diseases. By analyzing chromatin interactions in different cell types from the developing prefrontal cortex, the study aims to uncover how gene regulation is affected by genetic variants linked to conditions like autism. The approach involves advanced techniques such as ATAC sequencing to map chromatin accessibility and gene expression. Patients may benefit from insights gained about the biological pathways involved in these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants and adolescents, particularly those with neurodevelopmental disorders such as autism.
Not a fit: Patients with fully developed neuropsychiatric conditions or those outside the specified age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic factors contributing to neuropsychiatric disorders, potentially guiding new treatment strategies.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation through 3D genome mapping, indicating that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Shen, Yin — University of California, San Francisco
- Study coordinator: Shen, Yin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.