Mapping the 3D structure of organs using advanced imaging techniques
Whole organ transcriptome reconstruction by dimensionality reduced fluorescent in situ hybridization
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11084504
This study is working on a new way to create detailed 3D maps of organs at the cellular level, which could help us understand how they work and improve treatments for diseases, making it easier for patients to get better care.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11084504 on ClinicalTrials.gov |
What this research studies
This research aims to develop a new method for mapping the three-dimensional structure of organs at a cellular level, which is crucial for understanding how organs function. The approach utilizes a novel technique called dimensionality reduced Fluorescent In Situ Hybridization (dredFISH) to capture detailed information about the molecular states of cells within the organ. By integrating this data with existing single-cell RNA sequencing information, the researchers hope to create a comprehensive map of organ structures that can enhance our understanding of physiology and disease. Patients may benefit from this research as it could lead to improved diagnostic and therapeutic strategies based on a better understanding of organ function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting organ function or structure, such as those with chronic diseases or tumors.
Not a fit: Patients with stable, non-progressive conditions that do not affect organ structure may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could provide patients with more accurate diagnoses and targeted treatments based on detailed organ mapping.
How similar studies have performed: Previous research using spatial transcriptomics has shown promise in mapping tissue structures, indicating that this approach may lead to significant advancements in the field.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOLLMAN, ROY — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: WOLLMAN, ROY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.