Mapping the 3D structure of organs using advanced imaging techniques
Official title: Whole organ transcriptome reconstruction by dimensionality reduced fluorescent in situ hybridization
Funded at University of California Los Angeles · NIH-11084504 · Data updated 2026-11-12
This study is working on a new way to create detailed 3D maps of organs at the cellular level, which could help us understand how they work and improve treatments for diseases, making it easier for patients to get better care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | May 6, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $618,766 |
| NIH project number | 5R01HG012925-02 |
| Project ID | NIH-11084504 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting organ function or structure, such as those with chronic diseases or tumors.
✕Less likely to help
Patients with stable, non-progressive conditions that do not affect organ structure may not receive direct benefits from this research.
What this research studies
This research aims to develop a new method for mapping the three-dimensional structure of organs at a cellular level, which is crucial for understanding how organs function. The approach utilizes a novel technique called dimensionality reduced Fluorescent In Situ Hybridization (dredFISH) to capture detailed information about the molecular states of cells within the organ. By integrating this data with existing single-cell RNA sequencing information, the researchers hope to create a comprehensive map of organ structures that can enhance our understanding of physiology and disease. Patients may benefit from this research as it could lead to improved diagnostic and therapeutic strategies based on a better understanding of organ function.
Why it matters
Potential benefit: If successful, this research could provide patients with more accurate diagnoses and targeted treatments based on detailed organ mapping.
How similar studies have gone: Previous research using spatial transcriptomics has shown promise in mapping tissue structures, indicating that this approach may lead to significant advancements in the field.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Wollman, Roy — University of California Los Angeles
- Study coordinator: Wollman, Roy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.