Mapping the 3-D structure of proteins involved in Alzheimer's disease
Official title: Project 2: 3-D Molecular atlas of AD proteinopathy
Funded at Columbia University Health Sciences · NIH-10935939 · Data updated 2026-11-12
This study is looking at how certain proteins related to Alzheimer's disease are arranged in the brain, which could help us understand the disease better and find new ways to treat it for people living with Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $551,383 |
| NIH project number | 5U19AG074862-02 |
| Project ID | NIH-10935939 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related neurodegenerative conditions.
✕Less likely to help
Patients with non-neurodegenerative conditions or those without cognitive decline may not receive any benefit from this research.
What this research studies
This research investigates the complex distribution and organization of proteins associated with Alzheimer's disease in human brain tissue. By using advanced spatial techniques, the study aims to visualize how amyloid-beta plaques and tau tangles, along with other protein aggregates, are arranged in the brain. This approach will help researchers understand the cellular changes that occur in Alzheimer's, which could lead to better-targeted treatments. Patients may benefit from insights gained about the disease's progression and potential therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in using spatial techniques to study proteinopathies, indicating that this approach could yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Menon, Vilas — Columbia University Health Sciences
- Study coordinator: Menon, Vilas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.