Mapping senescent cells in human tissues using advanced profiling techniques
PIXEL-seq-based spatial, multi-omic profiling for senescent cell mapping with single-cell resolution
This study is looking at special cells in our bodies that stop dividing and can make us age faster or get sick, using a new method to see exactly what these cells are like, and it hopes to find ways to help people live healthier and longer lives.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10916562 on NIH RePORTER |
What this research studies
This research focuses on identifying and characterizing senescent cells in human tissues, which are cells that have stopped dividing and can contribute to aging and various diseases. The approach involves a novel technique called PIXEL-seq, which allows for detailed spatial mapping of cellular states at a single-cell resolution. By analyzing the transcriptome, open chromatin, and proteome of these cells, the research aims to uncover specific markers of senescence and understand their role in healthspan and lifespan. Patients may benefit from insights that could lead to targeted therapies for age-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over the age of 21 who may be experiencing age-related conditions or diseases associated with cellular senescence.
Not a fit: Patients who are under 21 years old or those without conditions related to cellular aging may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for targeting and removing senescent cells, potentially enhancing healthspan and lifespan for patients.
How similar studies have performed: Other research has shown promise in using advanced profiling techniques to study cellular aging, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Gu, Liangcai — University of Washington
- Study coordinator: Gu, Liangcai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.