Mapping senescent cells in human tissues to understand aging and diseases.
Minnesota Tissue Mapping Center for Senescent Cells
['FUNDING_OTHER'] · UNIVERSITY OF MINNESOTA · NIH-10899778
This study is looking at how certain aging cells affect our health and diseases like Alzheimer's, and it's for anyone interested in understanding how these cells work in different parts of the body, which could help us find new ways to improve health as we age.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-10899778 on ClinicalTrials.gov |
What this research studies
This research investigates the role of senescent cells, which are linked to aging and various age-related diseases, including Alzheimer's. By establishing a Tissue Mapping Center, the project aims to create a detailed atlas of these cells in different human organs, such as adipose tissue, skeletal muscle, liver, and ovaries. The approach focuses on understanding how these cells interact with the immune system and their impact on health and disease. This knowledge could lead to new therapeutic strategies targeting aging processes rather than specific diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related conditions, particularly those at risk for Alzheimer's disease.
Not a fit: Patients with acute conditions unrelated to aging or those who are not elderly may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve health outcomes for aging individuals and those with age-related diseases.
How similar studies have performed: Previous research has shown promising results in targeting senescent cells in animal models, indicating potential for success in human applications.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NIEDERNHOFER, LAURA JANE — UNIVERSITY OF MINNESOTA
- Study coordinator: NIEDERNHOFER, LAURA JANE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease