Mapping RNA regulation in human immune cells
Official title: High Resolution Functional Maps of Enhancer RNA and Subcellular RNA Granules in Human Immune Cells
Funded at New York Medical College · NIH-11253113 · Data updated 2026-11-12
This study is looking at how certain RNA molecules work in your immune cells to help us understand diseases related to the immune system and metabolism, which could lead to better treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Medical College NIH-funded |
| Lab location | 1 site (Valhalla, United States) |
| Project start | January 15, 2025 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $407,440 |
| NIH project number | 7R35GM142979-05 |
| Project ID | NIH-11253113 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with immunometabolic diseases or those undergoing cancer immunotherapy.
✕Less likely to help
Patients with unrelated conditions or those not involved in immunometabolic diseases may not receive direct benefits from this research.
What this research studies
This research investigates how RNA is regulated in living human immune cells, focusing on the mapping of enhancer RNA (eRNA) and its role in gene expression. By creating high-resolution maps of eRNA in immune cells, the study aims to identify genetic variations that may contribute to diseases, particularly immunometabolic disorders. The approach involves analyzing subcellular compartments that affect RNA processing and trafficking, which could lead to new insights into disease mechanisms. Patients may benefit from a better understanding of how their immune responses are regulated at the molecular level.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for cancer immunotherapy by identifying key genetic factors that influence immune cell function.
How similar studies have gone: Previous research has shown promise in understanding RNA regulation and its implications for disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
New York Medical College
Valhalla, United States Active
Researchers
- Principal investigator: Kwak, Hojoong — New York Medical College
- Study coordinator: Kwak, Hojoong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.