Mapping RNA regulation in human immune cells
High Resolution Functional Maps of Enhancer RNA and Subcellular RNA Granules in Human Immune Cells
['FUNDING_OTHER'] · NEW YORK MEDICAL COLLEGE · NIH-11253113
This study is looking at how certain RNA molecules work in your immune cells to help us understand diseases related to the immune system and metabolism, which could lead to better treatments for patients like you.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK MEDICAL COLLEGE (nih funded) |
| Locations | 1 site (VALHALLA, UNITED STATES) |
| Trial ID | NIH-11253113 on ClinicalTrials.gov |
What this research studies
This research investigates how RNA is regulated in living human immune cells, focusing on the mapping of enhancer RNA (eRNA) and its role in gene expression. By creating high-resolution maps of eRNA in immune cells, the study aims to identify genetic variations that may contribute to diseases, particularly immunometabolic disorders. The approach involves analyzing subcellular compartments that affect RNA processing and trafficking, which could lead to new insights into disease mechanisms. Patients may benefit from a better understanding of how their immune responses are regulated at the molecular level.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with immunometabolic diseases or those undergoing cancer immunotherapy.
Not a fit: Patients with unrelated conditions or those not involved in immunometabolic diseases may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for cancer immunotherapy by identifying key genetic factors that influence immune cell function.
How similar studies have performed: Previous research has shown promise in understanding RNA regulation and its implications for disease, suggesting that this approach could yield valuable insights.
Where this research is happening
VALHALLA, UNITED STATES
- NEW YORK MEDICAL COLLEGE — VALHALLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KWAK, HOJOONG — NEW YORK MEDICAL COLLEGE
- Study coordinator: KWAK, HOJOONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer immunotherapy, anticancer immunotherapy, cancer immunotherapy, Disease, Disorder