Mapping RNA molecules in cells with high precision
Universally-applicable RNA mapping at subcellular and single-base resolution
This study is working on a new tool called SMOOTHY-FISH that helps scientists better see and understand RNA molecules in individual cells, which could lead to important discoveries about chronic diseases and disorders related to RNA.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10473389 on NIH RePORTER |
What this research studies
This research focuses on developing a new tool called SMOOTHY-FISH, which aims to enhance the mapping of RNA molecules within individual cells. By achieving high transcript-selectivity and single-base sensitivity, this project seeks to identify and quantify various RNA species, including those that are currently difficult to access. The approach involves creating a user-friendly platform that can generate reliable probe sets for specific RNA targets, thereby advancing our understanding of cell biology and developmental processes. Patients may benefit from insights gained through this research, particularly in relation to chronic diseases and disorders linked to RNA function.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with chronic diseases or disorders that may be influenced by RNA dynamics.
Not a fit: Patients with conditions unrelated to RNA function or those not affected by chronic diseases may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating chronic diseases by providing detailed insights into RNA behavior in cells.
How similar studies have performed: Previous research has shown success in RNA mapping technologies, but the specific approach of SMOOTHY-FISH represents a novel advancement in the field.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Ding, Fangyuan — University of California-Irvine
- Study coordinator: Ding, Fangyuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.