Mapping RNA molecules in cells to understand their functions and interactions
Rapid, Robust, and Routine: Multiplexed Microscopy for Spatially Resolved Whole-Transcriptomic Single-Cell Profiling and the Construction of Cell Atlases of all Tissues and in all Organisms
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-10912624
This study is looking at how RNA molecules work inside individual cells to understand how they communicate and change, which could help develop new ways to diagnose and treat diseases for patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10912624 on ClinicalTrials.gov |
What this research studies
This research utilizes advanced imaging techniques to analyze RNA molecules within individual cells, allowing scientists to see not only what genes are being expressed but also where these RNA molecules are located. By employing a method called MERFISH, the study aims to create detailed maps of cellular organization and interactions across various tissues and organisms. This approach could lead to significant insights into how cells communicate, how they change in different environments, and how these processes relate to diseases. Patients may benefit from the findings as they could lead to new diagnostic tools and therapies based on cellular behavior.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions that involve cellular dysfunction or abnormal gene expression.
Not a fit: Patients with stable, non-progressive conditions that do not involve cellular or molecular changes may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could provide groundbreaking insights into cellular functions that may lead to innovative treatments for various diseases.
How similar studies have performed: Other research utilizing similar imaging techniques has shown promising results in understanding cellular processes, indicating that this approach is both innovative and grounded in prior success.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOFFITT, JEFFREY — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: MOFFITT, JEFFREY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.