Mapping RNA and protein in human tissue samples with advanced sequencing technology
High-spatial-resolution ECM-inclusive multi-omics sequencing of human PFA and FFPE tissue slides
This study is testing a new technology that helps scientists take detailed pictures of RNA and proteins in human tissues, which could lead to better understanding and treatment of diseases for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10698076 on NIH RePORTER |
What this research studies
This research develops a cutting-edge sequencing technology that allows for the detailed mapping of RNA and proteins in human tissue samples. By using a novel barcoding method, the study aims to create high-resolution images of tissue at a cellular level, preserving the structure while providing comprehensive molecular information. This approach utilizes advanced microfluidic techniques and next-generation sequencing to analyze multiple samples efficiently and cost-effectively. Patients may benefit from insights gained about their tissues, which could lead to improved understanding and treatment of various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with specific tissue samples available for analysis, particularly those with conditions affecting the cardiovascular system or other related diseases.
Not a fit: Patients without available tissue samples or those with conditions unrelated to the focus of this research may not benefit.
Why it matters
Potential benefit: If successful, this research could enhance the precision of disease diagnosis and treatment by providing detailed molecular profiles of tissues.
How similar studies have performed: This approach is fundamentally new and has not been extensively tested in prior research, making it a novel endeavor.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Fan, Rong — Yale University
- Study coordinator: Fan, Rong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.