Mapping proteins involved in HIV and HBV infections to find a cure for HBV
Official title: A proteomics atlas of HIV/HBV infections for curing HBV
Funded at Emory University · NIH-11009298 · Data updated 2026-11-12
This study is looking at how the Hepatitis B virus and HIV interact with each other and our bodies, with the goal of finding new ways to treat people who have both infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $673,158 |
| NIH project number | 1R01AI181682-01A1 |
| Project ID | NIH-11009298 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are co-infected with HIV and HBV, particularly those at risk of severe liver disease.
✕Less likely to help
Patients who are solely infected with HBV or HIV without co-infection may not receive direct benefits from this research.
What this research studies
This research investigates the complex interactions between the Hepatitis B virus (HBV) and the human immunodeficiency virus (HIV) to better understand how these viruses affect each other and the host. By creating a detailed proteomics atlas, the study aims to identify key proteins that could be targeted for developing effective treatments. The research employs advanced techniques, including CRISPR screening, to explore how these viruses manipulate host cells and to discover potential therapeutic targets. Patients with chronic HBV and HIV co-infections may benefit from insights gained through this research, which seeks to pave the way for a functional cure for HBV.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that effectively cure chronic Hepatitis B infections.
How similar studies have gone: Previous research has shown promise in using proteomics and CRISPR approaches to understand viral infections, indicating potential for success in this novel investigation.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Michailidis, Eleftherios — Emory University
- Study coordinator: Michailidis, Eleftherios
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.