Mapping proteins in healthy and osteoarthritic cartilage
Establishing a Single-Cell Proteomic Atlas for Normal and Osteoarthritic Articular Cartilage
This study is looking at how the proteins in cartilage from people with osteoarthritis differ from those in healthy individuals, using a special technique to get a closer look at the cells involved, so we can learn more about the disease and find better ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11061821 on NIH RePORTER |
What this research studies
This research investigates the differences in protein expression in cartilage from patients with osteoarthritis (OA) compared to healthy individuals. Using a cutting-edge technique called mass cytometry, the study aims to analyze individual cells within cartilage to identify various cellular subpopulations and their roles in OA. By understanding these differences at a single-cell level, researchers hope to uncover new insights into the disease's progression and potential treatment targets. This approach also aims to complement existing data on gene expression to provide a more comprehensive view of OA pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with osteoarthritis who are undergoing treatment or evaluation for their condition.
Not a fit: Patients with non-degenerative joint conditions or those who do not have osteoarthritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for osteoarthritis by identifying specific cellular mechanisms involved in the disease.
How similar studies have performed: Previous research using single-cell proteomic techniques has shown promise in understanding complex diseases, suggesting that this approach could yield valuable insights for osteoarthritis as well.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Bhutani, Nidhi — Stanford University
- Study coordinator: Bhutani, Nidhi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.