Mapping proteins and genes in aging cells
Spatially-resolved protein and transcriptome mapping of senescent cells
This study is looking at special cells that stop dividing and can harm our tissues as we age, using new technology to better understand them, which could help find ways to improve health as we get older.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11178124 on NIH RePORTER |
What this research studies
This research aims to develop advanced technologies to identify and characterize senescent cells, which are cells that have stopped dividing and can negatively impact tissue health. By using innovative methods like imaging mass cytometry and transcriptomic digital spatial profiling, the researchers will analyze the unique features of these cells in various tissues, including the brain. This comprehensive profiling will help to understand how senescent cells contribute to age-related decline and may lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues or conditions associated with cellular senescence.
Not a fit: Patients who are not experiencing age-related decline or do not have conditions linked to senescent cells may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve health and function in aging individuals by targeting senescent cells.
How similar studies have performed: Previous research has shown promising results in characterizing senescent cells using advanced profiling techniques, indicating that this approach has potential for success.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Schafer, Marissa Joy — Mayo Clinic Rochester
- Study coordinator: Schafer, Marissa Joy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.