Mapping protein modifications in human tissues
A streamlined platform for phosphoproteome mapping of human tissues
This study is exploring a new way to create detailed maps of protein changes in human tissues, especially how these changes might affect cell behavior and contribute to diseases like cancer, with the hope that this information can lead to better diagnosis and treatment options for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Battelle Pacific Northwest Laboratories NIH-funded |
| Lab location | 1 site (Richland, United States) |
| Project ID | NIH-10707474 on NIH RePORTER |
What this research studies
This research focuses on developing a new platform to create detailed maps of protein modifications, specifically phosphorylation, in human tissues. By utilizing advanced technologies, the project aims to analyze how these modifications affect cell function and contribute to diseases like cancer. Patients may benefit from insights gained about tissue heterogeneity and its impact on health, which could lead to improved diagnostic and therapeutic strategies. The research employs innovative techniques for analyzing small numbers of cells, enhancing our understanding of cellular processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or other conditions where tissue heterogeneity plays a significant role.
Not a fit: Patients with conditions unrelated to tissue heterogeneity or those not requiring detailed protein modification analysis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for various cancers and other diseases.
How similar studies have performed: While the approach is innovative, similar studies have shown promise in advancing our understanding of cellular functions through proteomic analysis.
Where this research is happening
Richland, United States
- Battelle Pacific Northwest Laboratories — Richland, United States (Active)
Researchers
- Principal investigator: Shi, Tujin — Battelle Pacific Northwest Laboratories
- Study coordinator: Shi, Tujin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.