Mapping protein interactions to understand gene expression regulation
Extensive multiplexing of protein nucleic-acid interactions to comprehensively study gene expression regulation from chromatin to mRNA degradation
['FUNDING_R01'] · COLUMBIA UNIV NEW YORK MORNINGSIDE · NIH-11017051
This study is exploring how proteins and nucleic acids work together to control gene activity, using a new technology to see these interactions in different cells, including those related to diseases like ALS, to help us understand gene regulation better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIV NEW YORK MORNINGSIDE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11017051 on ClinicalTrials.gov |
What this research studies
This research investigates how proteins interact with nucleic acids to regulate gene expression, focusing on processes from chromatin modification to mRNA degradation. By developing a novel technology called Hi-P, the project aims to map multiple protein-nucleic acid interactions simultaneously, which could provide insights into gene regulation in various cell types, including those affected by diseases like Amyotrophic Lateral Sclerosis. The approach utilizes high-throughput sequencing to create comprehensive genomic maps, allowing researchers to study specific cell types or disease models more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Amyotrophic Lateral Sclerosis or those interested in the genetic mechanisms underlying this condition.
Not a fit: Patients with conditions unrelated to gene expression regulation or those not diagnosed with Amyotrophic Lateral Sclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of gene regulation mechanisms, potentially informing new treatments for conditions like Amyotrophic Lateral Sclerosis.
How similar studies have performed: Previous research has shown success in mapping protein-nucleic acid interactions, but this approach aims to significantly enhance the capabilities of existing methods, making it a novel advancement in the field.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIV NEW YORK MORNINGSIDE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JOVANOVIC, MARKO — COLUMBIA UNIV NEW YORK MORNINGSIDE
- Study coordinator: JOVANOVIC, MARKO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Amyotrophic Lateral Sclerosis Motor Neuron Disease