Mapping protein interactions involved in DNA repair
Official title: Core 3: Structural Biology and Biophysics (SBB) Core
Funded at University of Texas Hlth Science Center · NIH-10847793 · Data updated 2026-11-12
This study is looking at how certain proteins that help fix DNA work together and with DNA itself, using special techniques to create detailed maps of their interactions, which could help us better understand how our cells repair damage.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $204,387 |
| NIH project number | 1P01CA275717-01A1 |
| Project ID | NIH-10847793 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to DNA damage and repair, such as certain types of cancer.
✕Less likely to help
Patients with conditions unrelated to DNA repair mechanisms may not benefit from this research.
What this research studies
This research focuses on understanding how proteins involved in DNA repair interact with each other and with DNA itself. Using advanced techniques like Nuclear Magnetic Resonance (NMR) and other biophysical methods, the team will create detailed maps of protein binding sites at an atomic level. This approach is particularly important for studying proteins that are intrinsically disordered, which means they do not have a fixed structure but play crucial roles in cellular processes. By identifying key amino acids that mediate these interactions, the research aims to enhance our understanding of DNA repair mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for targeting DNA repair processes in various diseases, including cancer.
How similar studies have gone: Previous research has shown success in using similar biophysical approaches to study protein interactions, indicating a promising avenue for this investigation.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Libich, David Steven — University of Texas Hlth Science Center
- Study coordinator: Libich, David Steven
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.