Mapping protein interactions across the human proteome
Genome-wide structure-based analysis of protein-protein interactions and networks
['FUNDING_OTHER'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-11331565
The team builds computer tools and lab tests to map how proteins interact so researchers can find new drug and antibody targets for many diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11331565 on ClinicalTrials.gov |
What this research studies
From my perspective, researchers combine advanced computer algorithms with lab experiments to chart which proteins bind to each other across the proteome. They extend a long-standing PrePPI approach with structure-based models to predict interaction networks and assign functions. In the lab they measure binding strengths of designed protein variants and use free energy calculations to help design antibodies with stronger binding. The project mixes large-scale computation, experimental binding assays, and software tools so other scientists can use the results to explore disease mechanisms.
Who could benefit from this research
Good fit: People with conditions tied to protein interaction problems—such as certain neurological disorders, immune diseases, or cancers—or those willing to donate samples for research could be relevant for follow-up studies.
Not a fit: Patients seeking immediate treatment or those with conditions unrelated to protein-interaction targets are unlikely to get direct personal benefit from this basic and preclinical research.
Why it matters
Potential benefit: If successful, this work could reveal new biological targets and guide design of better drugs and antibodies for a range of diseases.
How similar studies have performed: Related computational and structural biology efforts, including earlier PrePPI work, have predicted interactions and helped improve antibodies, but applying these methods at a proteome-wide scale is still relatively new and challenging.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HONIG, BARRY H — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: HONIG, BARRY H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.