Mapping pediatric cancer cells and their responses to treatment
Center for pediatric tumor cell atlas
This study is looking at different types of childhood cancers to see how they respond to treatments like chemotherapy and CAR-T cell therapy, with the hope of creating helpful resources for doctors and researchers to improve care for kids with cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10479967 on NIH RePORTER |
What this research studies
This research focuses on understanding pediatric cancers, which are significantly different from adult cancers. It aims to characterize three major types of pediatric malignancies that account for a large portion of childhood cancer deaths. By using advanced technologies to analyze tumor cells and their environment, the research will track how these cancers respond to various treatments, including chemotherapy and CAR-T cell therapy. The goal is to create detailed tumor atlases that will serve as a valuable resource for researchers and clinicians.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with high grade glioma, high risk neuroblastoma, or very high risk acute lymphoblastic leukemia.
Not a fit: Patients with adult cancers or those not diagnosed with the specified pediatric malignancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and outcomes for children with cancer.
How similar studies have performed: Previous research has shown promise in characterizing pediatric cancers, but this approach aims to provide a novel and comprehensive mapping of tumor responses.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Tan, Kai — Children's Hosp of Philadelphia
- Study coordinator: Tan, Kai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.