Mapping oxygen extraction in multiple sclerosis using MRI
Official title: MRI-Based Quantitative Mapping of Oxygen Extraction Fraction in MS
Funded at State University of New York at Buffalo · NIH-11060985 · Data updated 2026-11-12
This study is looking at how MRI can help us see how well your brain is using oxygen, which could give us important clues about how multiple sclerosis is affecting you and how well treatments are working.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $351,657 |
| NIH project number | 5R01NS136369-02 |
| Project ID | NIH-11060985 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with multiple sclerosis who are 21 years or older.
✕Less likely to help
Patients with other neurological disorders unrelated to multiple sclerosis may not benefit from this research.
What this research studies
This research investigates how to use MRI to measure the oxygen extraction fraction (OEF) in patients with multiple sclerosis (MS). By quantifying how much oxygen brain tissues extract from the blood, the study aims to identify sensitive biomarkers that can help monitor disease progression and treatment effectiveness. The approach focuses on understanding the relationship between OEF, mitochondrial dysfunction, and inflammation in MS lesions. This could lead to improved diagnostic tools and better management of MS.
Why it matters
Potential benefit: If successful, this research could provide a new method for early detection and monitoring of multiple sclerosis, potentially leading to more effective treatments.
How similar studies have gone: Previous studies have shown promise in using imaging techniques to assess biomarkers in neurological disorders, suggesting that this approach could be effective.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Cho, Junghun — State University of New York at Buffalo
- Study coordinator: Cho, Junghun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.