Mapping mutation rates and selection impacts on neuropsychiatric diseases
Refining mutation rates and measures of purifying selection with an application to understanding the impact of non-coding variation on neuropsychiatric diseases
This study is looking at how changes in our genes and natural selection might play a role in brain-related conditions, helping us understand the genetic factors behind these disorders better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10665606 on NIH RePORTER |
What this research studies
This research aims to create a detailed map of mutation rates and the effects of natural selection across the human genome, focusing on how these factors contribute to neuropsychiatric diseases. By utilizing advanced statistical methodologies and large-scale sequencing data, the project will estimate germline mutation rates and explore the influence of various genomic features on these rates. The study will also address the complexities of human demographic changes that affect the inference of genetic selection, ultimately providing insights into the genetic underpinnings of neuropsychiatric disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of neuropsychiatric disorders or those diagnosed with such conditions.
Not a fit: Patients without any neuropsychiatric disorders or those not related to the genetic factors being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of the genetic factors contributing to neuropsychiatric diseases, potentially leading to improved diagnostic and therapeutic strategies.
How similar studies have performed: Other research has shown success in mapping genetic variations and their impacts on diseases, suggesting that this approach could yield valuable insights as well.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: He, Xin — University of Chicago
- Study coordinator: He, Xin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.