Mapping molecular interactions in diabetes and its complications
Extremely high-throughput mapping of protein, RNA, and chromatin interactions in health and disease
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10890100
This study is looking at how diabetes affects the way proteins and genes work together in cells, with the hope of finding new ways to help improve wound healing for people with diabetes.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10890100 on ClinicalTrials.gov |
What this research studies
This research focuses on developing advanced technologies to map the interactions between proteins, RNA, and chromatin in cells affected by diabetes. By utilizing a method called PRACI, researchers aim to create detailed maps of molecular interactions that occur in both healthy and diseased states. This approach will allow for a better understanding of how diabetes affects gene expression and contributes to complications such as diabetic wounds. The goal is to identify key molecular changes in endothelial cells that can inform new treatment strategies for improving wound healing in diabetic patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes, particularly those experiencing complications such as diabetic wounds.
Not a fit: Patients without diabetes or those not experiencing any complications related to diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diabetic wounds and better management of diabetes-related complications.
How similar studies have performed: Other research has shown promise in mapping molecular interactions, suggesting that this approach could yield significant insights into diabetes and its complications.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHONG, SHENG — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: ZHONG, SHENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Diabetes Mellitus, Disease, Disorder