Mapping Molecular Changes in Alzheimer's Disease Brain Regions
Creating a region- specific biomolecular atlas of the brain of Alzheimer’s disease
This project is mapping the molecular changes in different parts of the brain affected by Alzheimer's disease to better understand how it develops.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11134756 on NIH RePORTER |
What this research studies
Many diseases of aging, including Alzheimer's disease, are linked to significant metabolic changes involving proteins, sugars, and fats. We know these changes are not uniform across the brain, with some areas being more severely affected than others. This work aims to create a detailed, region-specific map of these molecular patterns in the brain. By using advanced imaging technology, we can see exactly where these changes occur. This will provide a more complete picture of how Alzheimer's disease progresses.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future clinical applications would target individuals with Alzheimer's disease or those at risk.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: This work could lead to a deeper understanding of Alzheimer's disease, potentially identifying new targets for future treatments that are tailored to specific brain regions.
How similar studies have performed: While the concept of metabolic changes in Alzheimer's disease is known, this approach uses advanced imaging to provide a more detailed, region-specific molecular map, which is a novel and comprehensive approach.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Li, Lingjun — University of Wisconsin-Madison
- Study coordinator: Li, Lingjun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.