Mapping metabolism to improve heart failure treatment
Metabolomics Mapping and Cardiac Resynchronization
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-10326338
This study is looking at how a treatment called cardiac resynchronization therapy (CRT) can help people with early-stage heart failure feel better by improving their heart function, and it wants to see if starting this treatment early can make a difference, especially for men and women.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10326338 on ClinicalTrials.gov |
What this research studies
This research investigates how cardiac resynchronization therapy (CRT) can improve heart function in patients with early-stage heart failure. By analyzing metabolic changes in the heart, the study aims to identify which metabolic pathways are affected by CRT and how these changes can lead to better outcomes for patients. The research focuses on patients with mild left ventricular systolic dysfunction and aims to determine if early intervention can prevent further deterioration of heart function. The study also explores potential differences in treatment response between men and women.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older with mild left ventricular systolic dysfunction and left bundle branch block.
Not a fit: Patients with advanced heart failure or those without left bundle branch block may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for heart failure, potentially reducing hospitalizations and enhancing quality of life for patients.
How similar studies have performed: Previous research has shown promising results with cardiac resynchronization therapy, but this specific approach focusing on metabolic mapping is novel.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHA, YONG-MEI — MAYO CLINIC ROCHESTER
- Study coordinator: CHA, YONG-MEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.