Mapping long noncoding RNAs inside colon cells
Spatial subcellular mapping of the intestinal LncRNAome
['FUNDING_OTHER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11238063
This project maps long noncoding RNAs inside colon cells to learn how they influence inflammation in people with ulcerative colitis.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11238063 on ClinicalTrials.gov |
What this research studies
You would learn that researchers are mapping exactly where long noncoding RNAs (lncRNAs) sit inside different parts of colon cells using advanced imaging and sequencing methods. They will study colon tissue and cell models, including samples related to ulcerative colitis, to find lncRNAs that move to organelles like mitochondria. The team will look at how those lncRNAs interact with proteins that control cell energy and inflammation and compare patterns between healthy and inflamed tissue. The goal is to identify RNA-related mechanisms that could be targeted to reduce intestinal inflammation.
Who could benefit from this research
Good fit: Adults with a diagnosis of ulcerative colitis who can provide colon tissue samples or participate in sample collection at the study site would be ideal candidates.
Not a fit: People without ulcerative colitis or those unable or unwilling to provide tissue samples are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this could point to new molecular targets that might reduce inflammation and protect the intestinal barrier in ulcerative colitis.
How similar studies have performed: A few early studies have linked certain lncRNAs to intestinal barrier function and inflammation, but detailed subcellular mapping in patient tissue is relatively new and not yet widely validated.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GALIA, LIRAZ — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: GALIA, LIRAZ
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.