Mapping lipid changes in the brain related to Alzheimer's disease
Spatial dysregulation of the lipidome in Alzheimers disease human and mouse brain
This study is looking at how fat processing in the brain changes in different areas and cell types in people with Alzheimer's disease, hoping to find clues that could lead to better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10893625 on NIH RePORTER |
What this research studies
This research investigates how lipid metabolism in the brain differs across various regions and cell types in Alzheimer's disease. By creating a detailed map of lipid profiles, the study aims to identify specific metabolic changes associated with the disease. The researchers will focus on understanding how certain genes linked to Alzheimer's risk affect lipid metabolism. This innovative approach could provide valuable insights into the underlying mechanisms of Alzheimer's and help develop targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those at risk due to genetic factors such as APOE-ε4.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating Alzheimer's disease by targeting lipid metabolism.
How similar studies have performed: While lipidomics in peripheral blood is well-established, the application of spatially-resolved lipidomics in the brain is a novel approach that has not been extensively tested.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Mcintire, Laura Beth Johnson — Weill Medical Coll of Cornell Univ
- Study coordinator: Mcintire, Laura Beth Johnson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.