Mapping knee pain in osteoarthritis based on activity and rest
Official title: Precision Mapping of Knee Pain in Osteoarthritis: Understanding differences between pain with activity and rest
Funded at Rush University Medical Center · NIH-11037437 · Data updated 2026-11-12
This study is looking at how knee pain feels different when you're active compared to when you're resting, specifically for people with osteoarthritis, to help improve ways to manage that pain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 13, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $83,970 |
| NIH project number | 3UC2AR082186-01S2 |
| Project ID | NIH-11037437 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with knee osteoarthritis who experience varying pain levels during activity and at rest.
✕Less likely to help
Patients with knee pain not related to osteoarthritis or those with other underlying conditions may not benefit from this research.
What this research studies
This research investigates how knee pain in osteoarthritis patients differs between activity and rest. It aims to collect detailed data on the location and severity of knee pain, linking this information to tissue-level changes observed through advanced imaging techniques like MRI. By understanding these differences, the research seeks to enhance pain management strategies for individuals suffering from osteoarthritis. The study is part of a larger initiative focused on restoring joint health and function.
Why it matters
Potential benefit: If successful, this research could lead to more effective pain management strategies tailored to the specific pain experiences of osteoarthritis patients.
How similar studies have gone: Other research has shown promise in using pain phenotyping and imaging techniques to better understand pain mechanisms in osteoarthritis, indicating that this approach is both relevant and potentially impactful.
Where this research is happening
-
Rush University Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Malfait, Anne-Marie — Rush University Medical Center
- Study coordinator: Malfait, Anne-Marie
Related research
Other NIH-funded projects on the same topics.
-
Understanding how knee pain and knee obesity and muscle loss affect knee osteoarthritis
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-
Identifying OA subtypes and early warning signs before joint damage
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-
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Aberrant mechano-oxygen coupling linked to zinc-rich mineralization in osteoarthritis
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Notch signaling in TMJ osteoarthritis: uncovering mechanisms and new targets
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Nanoparticles delivering an sPLA2 blocker for knee osteoarthritis
This project uses tiny, drug-filled nanoparticles to deliver an sPLA2-blocking medicine into the knee to reduce inflammation and slow knee osteoarthritis in people with painful knee OA.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.