Mapping intracellular pressure in cells
High-Throughput, Multiplexing-Ready Intracellular Pressure Probes
This study is exploring how the pressure inside cells affects how they move, change shape, and grow, using tiny sensors to get real-time information, which could help us understand more about how cells work.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10705580 on NIH RePORTER |
What this research studies
This research focuses on understanding how intracellular pressure affects cell movement, shape, and growth. It aims to develop advanced nano-sized probes that can measure pressure variations within individual cells at a very small scale. By using innovative DNA-based scaffolds and aquaporin molecules, the researchers will create sensors that can provide real-time data on how pressure influences cellular processes like migration and division. This could lead to new insights into cell behavior and function.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with conditions that affect cell movement or proliferation, such as cancer or autoimmune diseases.
Not a fit: Patients with stable, non-progressive conditions that do not involve cellular motility or proliferation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cellular mechanics, potentially leading to breakthroughs in treating diseases related to cell motility and function.
How similar studies have performed: While the approach of using nano-sized sensors for intracellular pressure measurement is innovative, similar technologies have shown promise in other areas of cellular research, indicating potential for success.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Chen, Yun — Johns Hopkins University
- Study coordinator: Chen, Yun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.