Mapping interactions between human cell surface proteins and secreted ligands
A Global Map of Interactions Among Human Cell Surface Proteins and Secreted Ligands
This study is looking at how proteins on the surface of our cells interact with proteins that are released into the body, which could help us understand important processes in health and disease, and ultimately lead to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-10922709 on NIH RePORTER |
What this research studies
This research aims to create a comprehensive map of how human cell surface proteins interact with secreted proteins, which are crucial for various biological processes. By studying these interactions, researchers hope to understand their roles in human physiology and disease. The project involves testing millions of potential interactions to identify key relationships that could inform therapeutic strategies. Patients may benefit from insights gained about how these proteins influence immune responses and other critical functions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions influenced by cell surface protein interactions, such as cancer or autoimmune diseases.
Not a fit: Patients with conditions unrelated to cell surface protein interactions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for diseases by enhancing our understanding of cell communication.
How similar studies have performed: Other research has successfully mapped protein interactions, indicating that this approach has potential for significant breakthroughs in understanding disease mechanisms.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Zinn, Kai G — California Institute of Technology
- Study coordinator: Zinn, Kai G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.