Mapping immune responses in heart transplant patients affected by cytomegalovirus
Official title: High-dimensional single-cell mapping to define immune signatures of cytomegalovirus-associated rejection in cardiac transplantation
Funded at Brigham and Women's Hospital · NIH-11087518 · Data updated 2026-11-12
This study is looking at how a virus called cytomegalovirus (CMV) impacts the immune system in people who have received a heart transplant, with the goal of finding ways to help manage any complications that might arise from the virus.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 24, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $169,560 |
| NIH project number | 5K08HL157725-05 |
| Project ID | NIH-11087518 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are heart transplant recipients who are experiencing or are at risk for complications related to cytomegalovirus.
✕Less likely to help
Patients who have not undergone heart transplantation or those without CMV-related complications may not benefit from this research.
What this research studies
This research investigates how cytomegalovirus (CMV) affects the immune response in patients who have undergone heart transplantation. By analyzing immune cells at a single-cell level, the study aims to understand the mechanisms behind CMV-related rejection of heart grafts. The approach involves advanced techniques like single-cell RNA sequencing to identify specific immune signatures that contribute to rejection. This knowledge could lead to better management strategies for transplant patients facing complications from CMV.
Why it matters
Potential benefit: If successful, this research could improve treatment strategies for heart transplant patients, reducing the risk of rejection and associated complications.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in transplant patients, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Sen, Pritha — Brigham and Women's Hospital
- Study coordinator: Sen, Pritha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.