Mapping immune cells in precancerous oral lesions
Official title: Single-cell immune landscape in the oral dysplasia's malignant transformation
Funded at University of the Pacific-Stockton · NIH-10896274 · Data updated 2026-11-12
This study is looking at the immune system in patients with oral dysplasia, a condition that can lead to cancer, to find out which immune features might show if the condition is getting worse, with the hope of helping doctors create better treatments for those at risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of the Pacific-Stockton NIH-funded |
| Lab location | 1 site (Stockton, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $171,880 |
| NIH project number | 5R16GM150790-02 |
| Project ID | NIH-10896274 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with oral dysplasia who are being monitored for potential progression to cancer.
✕Less likely to help
Patients with no history of oral dysplasia or those who have already developed invasive oral cancer may not benefit from this research.
What this research studies
This research investigates the immune environment in oral dysplasia, a precancerous condition that can lead to oral cavity squamous cell carcinoma (OCSCC). By analyzing patient tongue biopsies using advanced imaging technology and machine learning, the study aims to identify immune features that indicate the risk of malignant transformation. The goal is to create a detailed atlas of immune cells in these lesions, which could help in developing targeted therapies for at-risk patients. Patients with oral dysplastic lesions may benefit from insights gained through this research.
Why it matters
Potential benefit: If successful, this research could lead to better prognostic tools and targeted therapies for patients with oral dysplasia at risk of developing cancer.
How similar studies have gone: Other research has shown promise in using similar high-dimensional imaging and machine learning approaches to analyze cancer-related immune environments, indicating potential for success in this novel application.
Where this research is happening
-
University of the Pacific-Stockton
Stockton, United States Active
Researchers
- Principal investigator: Han, Xiaoyuan — University of the Pacific-Stockton
- Study coordinator: Han, Xiaoyuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.