Mapping immune cell organization in tuberculosis granulomas
Deep spatial immune profiling of granulomas and M. tuberculosis adaptation to disease and treatment
['FUNDING_R01'] · EMORY UNIVERSITY · NIH-10988254
This study is looking at how the way immune cells are organized and talk to each other in clusters called granulomas affects how well the body fights off tuberculosis (TB) and responds to treatment, and it's designed for anyone interested in understanding more about TB and how to improve its treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10988254 on ClinicalTrials.gov |
What this research studies
This research investigates how the arrangement and communication of immune cells within granulomas affect the body's response to Mycobacterium tuberculosis (Mtb) infection and treatment. By developing a TB Granuloma Information System (TB-GIS), the study aims to create detailed geospatial maps of granulomas, which will help researchers understand the immune functions that either support or hinder Mtb survival. The approach utilizes advanced imaging techniques to analyze the immune environment and bacterial behavior in different granuloma types, providing insights into how these factors influence treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary tuberculosis who are undergoing treatment.
Not a fit: Patients with non-tuberculous infections or those who do not have active tuberculosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating tuberculosis by enhancing our understanding of how to manipulate the immune response.
How similar studies have performed: Other research has shown promise in understanding immune responses in tuberculosis, but this specific approach using high-plex imaging for spatial profiling is relatively novel.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RENGARAJAN, JYOTHI — EMORY UNIVERSITY
- Study coordinator: RENGARAJAN, JYOTHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacterial disease treatment, bacterial infectious disease treatment