Mapping how water moves across the blood-brain barrier using MRI
Non-invasive MRI mapping of BBB water exchange rate and permeability
This study is looking at a new, gentle MRI method to see how well the blood-brain barrier is working, which is important for keeping your brain safe, and it could help spot early signs of brain health issues as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11141776 on NIH RePORTER |
What this research studies
This research investigates a non-invasive MRI technique designed to assess the function of the blood-brain barrier (BBB), which protects the brain from harmful substances. By using a specialized method called diffusion prepared pseudo-continuous arterial spin labeling (OP-pCASL), the study aims to measure the water exchange rate and permeability of the BBB. This could help identify early signs of neurodegenerative disorders by detecting subtle dysfunctions in the BBB. The research will focus on understanding how these measurements relate to aging and other factors that may affect brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults or individuals at risk for neurodegenerative disorders.
Not a fit: Patients with acute neurological conditions or those who do not have any risk factors for neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better management of neurodegenerative diseases.
How similar studies have performed: Previous research has shown promise in using MRI techniques to assess BBB function, indicating that this approach could be effective.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Wang, Danny Jj — University of Southern California
- Study coordinator: Wang, Danny Jj
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.