Mapping how the subthalamic nucleus affects decision making in the brain
Using intracranial recording, stimulation, and computational modeling to map role of the subthalamic nucleus in human decision making
This study is looking at how a part of the brain called the subthalamic nucleus affects decision-making in people with Parkinson's Disease, using special brain stimulation and computer models to see how brain activity relates to thinking and choices, which could help improve treatments for cognitive issues in the future.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10626762 on NIH RePORTER |
What this research studies
This research investigates the role of the subthalamic nucleus (STN) in decision-making processes, particularly in patients with Parkinson's Disease. By using deep brain stimulation (DBS) and advanced computational modeling, the study aims to understand how neural activity in the STN influences both normal and impaired cognitive functions. Patients will participate in decision-making tasks while their brain activity is recorded, allowing researchers to analyze the relationship between neural signals and cognitive behavior. The findings could lead to improved treatments for cognitive disorders associated with STN DBS.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Parkinson's Disease who experience cognitive challenges or side effects from deep brain stimulation.
Not a fit: Patients without Parkinson's Disease or those who do not experience cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance treatment strategies for cognitive disorders, potentially improving decision-making abilities in affected patients.
How similar studies have performed: Previous research has shown that deep brain stimulation can effectively treat motor symptoms in Parkinson's Disease, but the cognitive effects of targeting the STN are still being explored.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Ratcliff, Roger — Ohio State University
- Study coordinator: Ratcliff, Roger
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.