Mapping how stem cells adapt to inflammation during healing
Official title: Genetic mapping of the inflammatory adaption circuit in epithelial stem cells
Funded at University of Chicago · NIH-10906907 · Data updated 2026-11-12
This study is looking at how special cells in your skin that help heal wounds can still do their job even when there's inflammation, and it hopes to find new ways to help people with wounds that won't heal.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $410,000 |
| NIH project number | 5R35GM150610-02 |
| Project ID | NIH-10906907 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with chronic wounds or conditions that impair wound healing.
✕Less likely to help
Patients with acute injuries that heal normally may not receive direct benefits from this research.
What this research studies
This research investigates how epithelial stem cells, which are crucial for tissue repair, adapt to inflammatory environments during wound healing. The study utilizes advanced techniques like CRISPR to explore the genetic mechanisms that allow these stem cells to survive and function despite the presence of harmful immune cells. By understanding these processes, the research aims to uncover how stem cells maintain their ability to regenerate tissue while managing inflammation. This knowledge could lead to new strategies for treating nonhealing wounds and improving recovery from injuries.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for nonhealing wounds, benefiting millions of patients worldwide.
How similar studies have gone: Previous research has shown promising results in understanding stem cell behavior in inflammatory environments, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Miao, Yuxuan Phoenix — University of Chicago
- Study coordinator: Miao, Yuxuan Phoenix
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.