Mapping how specific proteins interact with DNA across different human tissues
Official title: A cell-type specific atlas of TF-element connectivity across human tissues
Funded at Broad Institute, INC. · NIH-11127249 · Data updated 2026-11-12
This study is looking at how certain proteins interact with our DNA in different parts of the body to understand how genes are turned on or off, which could help us learn more about the genetic causes of diseases and how they affect patients like you.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | June 10, 2025 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $315,061 |
| NIH project number | 1R03OD039985-01 |
| Project ID | NIH-11127249 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions or diseases that may be influenced by non-coding genetic variations.
✕Less likely to help
Patients with conditions unrelated to genetic variations in regulatory elements may not receive direct benefits from this research.
What this research studies
This research aims to create a detailed atlas that shows how transcription factors interact with DNA elements in various human tissues. By using advanced techniques like single-cell ATAC-seq and deep learning, the project will analyze how genes are activated and organized in both healthy and diseased states. This information could help identify how genetic variations affect gene regulation and contribute to diseases. Patients may benefit from insights into the genetic factors influencing their conditions.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic variations that contribute to diseases, potentially guiding personalized treatment strategies.
How similar studies have gone: Other research has shown success in using similar deep learning approaches to analyze genomic data, indicating a promising avenue for this type of investigation.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Buenrostro, Jason Daniel — Broad Institute, INC.
- Study coordinator: Buenrostro, Jason Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.