Mapping how skeletal stem cells work in bone health and injury.
Official title: Unbiased mapping of skeletal stem cell function at single cell resolution in homeostasis and injury.
Funded at New York University School of Medicine · NIH-10788450 · Data updated 2026-11-12
This study is looking at special cells in your bones that help with healing and staying strong, especially as we age or after an injury, to find better ways to keep our bones healthy and help them recover.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $180,857 |
| NIH project number | 5R21AR081268-02 |
| Project ID | NIH-10788450 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults or individuals with conditions that affect bone health, such as osteoporosis or previous fractures.
✕Less likely to help
Patients with acute bone injuries that do not involve stem cell function or those with non-skeletal related conditions may not benefit from this research.
What this research studies
This research investigates the behavior of skeletal stem and progenitor cells (SSPCs) in the bone, particularly how they function during aging and after injury. By examining these cells at a single-cell level, the study aims to identify the mechanisms that lead to bone degeneration and to enhance the body's ability to repair bone. The researchers will use advanced techniques to isolate and analyze these cells, which are difficult to identify due to their diverse locations and lack of specific markers. Understanding these processes could lead to new strategies for improving bone health and recovery.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bone fractures and degenerative bone diseases, enhancing recovery and quality of life for patients.
How similar studies have gone: Previous research has shown promise in understanding stem cell behavior in other tissues, suggesting that this approach could yield valuable insights into skeletal health.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Leucht, Philipp — New York University School of Medicine
- Study coordinator: Leucht, Philipp
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.