Mapping how skeletal stem cells work in bone health and injury.
Unbiased mapping of skeletal stem cell function at single cell resolution in homeostasis and injury.
This study is looking at special cells in your bones that help with healing and staying strong, especially as we age or after an injury, to find better ways to keep our bones healthy and help them recover.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10788450 on NIH RePORTER |
What this research studies
This research investigates the behavior of skeletal stem and progenitor cells (SSPCs) in the bone, particularly how they function during aging and after injury. By examining these cells at a single-cell level, the study aims to identify the mechanisms that lead to bone degeneration and to enhance the body's ability to repair bone. The researchers will use advanced techniques to isolate and analyze these cells, which are difficult to identify due to their diverse locations and lack of specific markers. Understanding these processes could lead to new strategies for improving bone health and recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults or individuals with conditions that affect bone health, such as osteoporosis or previous fractures.
Not a fit: Patients with acute bone injuries that do not involve stem cell function or those with non-skeletal related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bone fractures and degenerative bone diseases, enhancing recovery and quality of life for patients.
How similar studies have performed: Previous research has shown promise in understanding stem cell behavior in other tissues, suggesting that this approach could yield valuable insights into skeletal health.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Leucht, Philipp — New York University School of Medicine
- Study coordinator: Leucht, Philipp
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.