Mapping how ribosomal RNA is regulated in blood cell development
Official title: A map of ribosomal RNA regulation in human hematopoiesis
Funded at University of Pennsylvania · NIH-10975665 · Data updated 2026-11-12
This study is looking at how the production of ribosomes, which are important for making blood cells, is controlled in different types of blood cells, and it's for anyone interested in understanding how our blood cells develop and function better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $121,875 |
| NIH project number | 1R21HL175623-01 |
| Project ID | NIH-10975665 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with blood disorders or conditions affecting hematopoiesis.
✕Less likely to help
Patients with conditions unrelated to blood cell development or those not experiencing hematopoietic issues may not benefit from this research.
What this research studies
This research investigates the regulation of ribosomal RNA (rRNA) in the development of blood cells, focusing on how different types of blood cells have varying amounts of ribosomes. The team will utilize advanced bioinformatics tools to analyze existing datasets and create custom genome assemblies to better understand rRNA regulation. By examining the binding of transcription factors to rDNA, the research aims to uncover the mechanisms that control rRNA transcription, which is crucial for ribosome production in hematopoietic cells.
Why it matters
Potential benefit: If successful, this research could lead to new insights into blood cell development and potential therapies for blood disorders.
How similar studies have gone: While the specific approach of mapping rRNA regulation in hematopoiesis is novel, similar studies have successfully utilized bioinformatics to uncover regulatory mechanisms in other cellular processes.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Paralkar, Vikram R. — University of Pennsylvania
- Study coordinator: Paralkar, Vikram R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.