Mapping how proteins interact with RNA in human cells
A comprehensive binding and functional map of human RNA-binding proteins
['FUNDING_OTHER'] · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · NIH-10909889
This study is looking at how certain proteins in our cells interact with RNA, which is important for understanding how genes work and how they can affect health, and it's designed for anyone interested in the science behind genetic differences and diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CONNECTICUT SCH OF MED/DNT (nih funded) |
| Locations | 1 site (FARMINGTON, UNITED STATES) |
| Trial ID | NIH-10909889 on ClinicalTrials.gov |
What this research studies
This research aims to create a detailed map of how RNA-binding proteins (RBPs) interact with RNA elements in human cells. By studying two different human cell lines, the project will analyze the effects of depleting specific RBPs on gene regulation. This comprehensive mapping will help uncover the mechanisms behind genetic variation and diseases, providing insights into how these interactions influence human biology. The project also includes training and outreach efforts to standardize the findings for broader use.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or those interested in the biological mechanisms of gene regulation.
Not a fit: Patients with conditions unrelated to RNA-binding proteins or gene regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic diseases and improved strategies for their treatment.
How similar studies have performed: Previous research has shown promising results in mapping protein-RNA interactions, indicating that this approach has potential for significant advancements.
Where this research is happening
FARMINGTON, UNITED STATES
- UNIVERSITY OF CONNECTICUT SCH OF MED/DNT — FARMINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRAVELEY, BRENTON R. — UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
- Study coordinator: GRAVELEY, BRENTON R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.