Mapping how proteins interact with RNA during splicing in human cells
Official title: Comprehensive Maps of Early Spliceosome and Regulator Binding to Nascent RNA in Human Cells
Funded at University of California Los Angeles · NIH-10943551 · Data updated 2026-11-12
This study is looking at how proteins interact with new RNA in our cells to better understand the splicing process, which is important for how our genes work, and it could help us learn more about genetic disorders caused by mistakes in this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 17, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $639,134 |
| NIH project number | 1R01HG013670-01 |
| Project ID | NIH-10943551 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders that are known to involve splicing abnormalities.
✕Less likely to help
Patients with conditions unrelated to RNA splicing or those who do not have genetic disorders may not benefit from this research.
What this research studies
This research focuses on developing innovative methods to identify how proteins and ribonucleoprotein particles (RNPs) interact with nascent unspliced RNA in human cells. By creating detailed maps of these interactions, the study aims to enhance our understanding of the splicing process, which is crucial for gene expression. The researchers will utilize a technique called IPseq to analyze the binding sites of key splicing components, providing insights into the regulatory mechanisms involved in RNA processing. This work could lead to a better understanding of genetic disorders linked to splicing errors.
Why it matters
Potential benefit: If successful, this research could improve our understanding of genetic disorders related to splicing, potentially leading to new therapeutic strategies.
How similar studies have gone: Previous research has shown success in mapping RNA-protein interactions, indicating that this approach has the potential for significant findings.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Black, Douglas L — University of California Los Angeles
- Study coordinator: Black, Douglas L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.