Mapping how proteins change location and function in cells
Post-translational modification proteomics in 4D: Chemoenzymatic tools to map the dynamic spatial organization of eukaryotic signaling pathways
['FUNDING_OTHER'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-10471100
This study is looking at how proteins in our cells move and change their roles when they receive different signals, which could help us understand health and disease better, and ultimately benefit patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-10471100 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how proteins in eukaryotic cells change their location and function in response to various biological signals. By developing innovative tools that can selectively tag proteins with specific modifications, the researchers aim to create a detailed map of these changes over time and space within the cell. This approach utilizes advanced techniques in protein engineering and mass spectrometry to analyze the dynamic behavior of proteins, particularly those involved in critical signaling pathways related to health and disease. Patients may benefit from insights gained into how these processes affect various conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to protein signaling pathways, such as cancer or metabolic disorders.
Not a fit: Patients with conditions unrelated to protein modifications or signaling pathways may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating diseases by providing a deeper understanding of protein behavior in cells.
How similar studies have performed: Other research has shown promise in using similar proteomic approaches to understand cellular processes, indicating potential for success in this novel application.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEEKS, AMY M — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: WEEKS, AMY M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.