Mapping how polycystin channels are regulated in kidney disease
A comprehensive map of polycystin channel regulation and its implications in polycystic kidney disease
This study is looking at how certain channels in kidney cells work and how they might be linked to Autosomal Dominant Polycystic Kidney Disease (ADPKD), with the hope of finding new ways to help manage the condition and improve treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10894933 on NIH RePORTER |
What this research studies
This research investigates the regulation of polycystin channels, which are crucial for kidney function and are implicated in Autosomal Dominant Polycystic Kidney Disease (ADPKD). The study aims to understand how these channels are activated in primary cilia, which play a significant role in cellular signaling. By examining the molecular mechanisms that control the spatial and temporal regulation of these channels, the research seeks to uncover insights that could lead to new therapeutic strategies for managing ADPKD. Patients may benefit from a better understanding of their condition and potential new treatments derived from this knowledge.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Autosomal Dominant Polycystic Kidney Disease (ADPKD).
Not a fit: Patients with other forms of kidney disease unrelated to polycystin channels may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with polycystic kidney disease.
How similar studies have performed: Previous research has shown promise in understanding ion channel regulation, but this specific approach to polycystin channels is relatively novel.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Delling, Markus G — University of California, San Francisco
- Study coordinator: Delling, Markus G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.