Mapping how noncoding DNA controls genes in individual human cells
Decoding the Noncoding Regulatory Genome with Super-resolution via Single-cell Multiomics Integration
This project builds new computer tools to read how the noncoding parts of your DNA control gene activity in single cells and links those patterns to disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11138571 on NIH RePORTER |
What this research studies
From a patient point of view, researchers will use high-resolution single-cell data from human samples to build a personal map of gene regulation for different cell types. They will combine multiple data types and apply advanced machine learning to capture cell-specific and person-specific regulatory signals. The team aims to connect unusual regulatory patterns to disease-related changes so that we better understand causes of illness. If you provide a blood or tissue sample or share genomic data, your contribution could help create these personalized maps.
Who could benefit from this research
Good fit: Ideal candidates would be adults (21+) with a diagnosed condition of interest or adults willing to donate blood or tissue samples or share existing genomic data for research.
Not a fit: Children under 21 and people seeking immediate clinical treatment are unlikely to benefit directly from this computational and sample-based research.
Why it matters
Potential benefit: If successful, this work could improve understanding of disease mechanisms and point to more precise diagnostic markers or targets for future treatments.
How similar studies have performed: Related single-cell, multimodal studies have already revealed new regulatory patterns in cell types, but building compact, personal regulomes at scale is a newer and still-developing approach.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Zhang, Jing — University of California-Irvine
- Study coordinator: Zhang, Jing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.