Mapping how muscles use energy in the body
In vivo Mapping of Muscle Specific Metabolism
This study is looking at how our muscles use energy during exercise and how that changes as we get older, using a special imaging technique that doesn’t require any invasive procedures, to help us understand and improve muscle health as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10993577 on NIH RePORTER |
What this research studies
This research investigates muscle metabolism using a non-invasive imaging technique called Cr-amine chemical exchange saturation transfer (CrCEST). It aims to measure the energy reserves in muscles, specifically focusing on how phosphocreatine and adenosine triphosphate are utilized during exercise and how these processes change with age. By comparing different muscle groups, the study seeks to provide insights into the metabolic differences that occur as we age, potentially leading to better understanding and treatment of age-related muscle decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over the age of 21 who are interested in understanding muscle metabolism and its changes with age.
Not a fit: Patients with conditions that severely limit muscle function or those who are unable to undergo MRI procedures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for maintaining muscle health and function in aging populations.
How similar studies have performed: Previous studies using similar imaging techniques have shown promise in understanding muscle metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Reddy, Ravinder — University of Pennsylvania
- Study coordinator: Reddy, Ravinder
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.