Mapping how mammalian cells develop and differentiate
Building a Systematic, Comprehensive Mammalian Cell Fate Map
This study is looking at how mammal cells grow and change over time to help scientists understand how to improve healing and repair in the body, which could lead to better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project ID | NIH-10473094 on NIH RePORTER |
What this research studies
This research aims to create a detailed map of how mammalian cells develop and differentiate over time. By using advanced techniques like single-cell RNA sequencing and CRISPR-Cas9 genome editing, the project will trace the lineage of cells, linking their current state to their developmental history. This comprehensive mapping will help researchers understand the processes that guide cell differentiation and could lead to new cellular therapies for various conditions. Patients may benefit from insights gained about tissue repair and regeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that could benefit from cellular therapies, such as diabetes or neurodegenerative diseases.
Not a fit: Patients with stable, non-progressive conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative cellular therapies that repair or replace damaged tissues and organs.
How similar studies have performed: Other research has shown promise in using similar lineage tracing techniques, indicating potential for success in this novel approach.
Where this research is happening
Princeton, UNITED STATES
- Princeton University — Princeton, United States (Active)
Researchers
- Principal investigator: Chan, Michelle — Princeton University
- Study coordinator: Chan, Michelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.